Биоинформатический анализ генов и полиморфизмов, вовлеченных в старение и развитие заболеваний, ассоциированных с возрастом

A. A. Pakhomov; N. S. Karpova; O. P. Dmitrenko

doi:10.25557/2310-0435.2024.02.72-75

A. A. Pakhomov P.G. Demidov Yaroslavl’ State University, Yaroslavl’, Russian Federation http://orcid.org/0009-0008-1221-5005
N. S. Karpova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0001-6391-4908
O. P. Dmitrenko Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0002-2067-0971

DOI: https://doi.org/10.25557/2310-0435.2024.02.72-75

Keywords: aging, bioinformatics, polymorphisms, age-associated diseases

Abstract

The aim of the study was to perform a bioinformatic analysis of gene’s polymorphisms, associated with ageing and age-associated diseases.

Materials and methods. Analysis of genes was performed with the use of information, obtained from the database of genome-wide association studies GWAS Catalog. String-DB database (v. 12.0) was used for analysis of protein-protein interactions (PPI).

Results. 7676 unique genes have been identified, the polymorphisms of which are associated with the development of age-associated diseases. The association of molecular functions of a number of genes (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 and MAPT) and their protein products with aging and age-associated diseases has been revealed.

Bioinformatic analysis of genes and polymorphisms involved in ageing and development

Abstract