Современные аспекты физиологии эндотелиального барьера и его нарушений при сепсисе

A. A. Kubatiev; T. G. Borovaya; V. G. Zhuhovickij; M. N. Cherkasova; S. G. Andreevskaya; N. V. Shevlyagina

doi:10.25557/2310-0435.2018.03.5-13

A. A. Kubatiev Institute of General Pathology and Pathophysiology, Moscow, Russia
T. G. Borovaya The Honorable Academician N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia
V. G. Zhuhovickij The Honorable Academician N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, Russia
M. N. Cherkasova The Honorable Academician, N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia
S. G. Andreevskaya The Honorable Academician N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia
N. V. Shevlyagina The Honorable Academician N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia

DOI: https://doi.org/10.25557/2310-0435.2018.03.5-13

Keywords: endothelium, glycocalix, permeability, sepsis

Abstract

The review focuses on structural and functional peculiarities of the glycocalyx and intercellular endothelium compounds in normal conditions and sepsis. The authors addressed the role of plasma albumin and enzymes in maintaining the physiological status of glycocalyx, mechanisms of destruction of the glycocalyx, and markers of this process in sepsis, including results obtained on experimental models of glycocalyx recovery. New information is provided on structural components of endothelial intercellular connections and their normal interactions as a part of tight junctions, adherence junctions, and gap junctions. Roles of intercellular compounds in physiological barrier-transport processes of the endothelium and in disorders of endothelial permeability in sepsis are discussed.

Modern aspects in the physiology of endothelial barrier and its disorders in sepsis

Abstract