Changes in GPX1, RHOA and NKIRAS1 gene expression profiles as potential diagnostic markers for non-small cell lung cancer

  • I. V. Pronina Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-0423-7801
  • V. I. Loginov Institute of General Pathology and Pathophysiology, Moscow, Russia; Medical Genetics Research Center, Moscow, Russia http://orcid.org/0000-0003-2668-8096
  • D. S. Khodyrev Federal Scientific and Clinical Center of Specialized Medical Assistance and Medical Technologies of the Federal Biomedical Agency of Russia, Moscow, Russia
  • T. P. Kazubskaya N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
  • E. A. Braga Institute of General Pathology and Pathophysiology, Moscow, Russia; Medical Genetics Research Center, Moscow, Russia http://orcid.org/0000-0001-5188-4094
DOI: https://doi.org/10.25557/2310-0435.2018.03.116-120
Keywords: non-small cell lung cancer, lung adenocarcinoma, squamous cell lung cancer, gene expression level, marker set, genes RHOA, GPX1 and NKIRAS1

Abstract

Lung cancer is distinguished by an extremely high prevalence and a high mortality rate due to its late detection and unavailability of methods for early diagnosis. Changes in gene expression were evaluated using quantitative RT-PCR. Expression of several chromosome 3 genes (specifically, RHOA, GPX1, and NKIRAS1) was shown to be increased 5 or more times in most samples of non-small cell lung cancer (NSCLC) and its histological subtypes, lung adenocarcinoma (AC) and squamous cell lung cancer (SLC). When a combination of three genes, RHOA, GPX1 and NKIRAS1, was used increased expression was detected in 85% (33/39) of NSCLC samples, including 78% (18/23) of SLC samples and 94% of AC (15/16) samples. Interestingly, when only samples from early-stage cancer (I/II) patients were analyzed, the sensitivity of the proposed set of genes was preserved and even somewhat increased.

Published
2018-12-31
How to Cite
Pronina, I. V., Loginov, V. I., Khodyrev, D. S., Kazubskaya, T. P., & Braga, E. A. (2018). Changes in GPX1, RHOA and NKIRAS1 gene expression profiles as potential diagnostic markers for non-small cell lung cancer. Patogenez (Pathogenesis), 16(3), 116-120. https://doi.org/10.25557/2310-0435.2018.03.116-120
Issue
Vol. 16 No. 3 (2018): Pathogenesis
Section
Brief reports