Therapeutic potential of exosomes and their derivatives

  • I. Yu. Malyshev A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-2381-9612
  • L. V. Kuznetsova A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
  • O. P. Budanova Institute of General Pathology and Pathophysiology, Moscow, Russia
DOI: https://doi.org/10.25557/2310-0435.2018.03.129-131
Keywords: exosomes, nanoparticles, nanovesicles, cells, therapy

Abstract

This review presents current data on mechanisms for diagnosis, planning, and evaluation of success in the treatment of various diseases using exosomes as nanocarriers (i.e., nanovesicles for efficient delivery of molecules). In recent years, a large number of different, mainly synthetic drug delivery systems has been developed. Disadvantages of these systems are poor biocompatibility and organic inability to deliver high-precision loaded substances. Compared with synthetic drug delivery systems, exosomes due to their natural origin may provide great advantages, such as better biocompatibility and increased resistance to detrimental effects of the immune system. This review describes in detail a technology of nanostructure production, the development and production of so-called fully synthetic exosome-like nanovesicles using bionanotechnology, and advantages and disadvantages of these methods.

Published
2018-12-31
How to Cite
Malyshev, I. Y., Kuznetsova, L. V., & Budanova, O. P. (2018). Therapeutic potential of exosomes and their derivatives. Patogenez (Pathogenesis), 16(3), 129-131. https://doi.org/10.25557/2310-0435.2018.03.129-131
Issue
Vol. 16 No. 3 (2018): Pathogenesis
Section
Brief reports