Molecular mechanisms of neutrophil apoptosis (review)

  • I. A. Shchepetkin Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA; National Research Tomsk Polytechnic University, Tomsk, Russian Federation
  • O. P. Budanova Institute of General Pathology and Pathophysiology, Moscow, Russia
  • I. Yu. Malyshev Institute of General Pathology and Pathophysiology, Moscow, Russia; A.I.Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia http://orcid.org/0000-0002-2381-9612
  • D. N. Atochin National Research Tomsk Polytechnic University, Tomsk, Russia; Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, 02129, USA http://orcid.org/0000-0002-2405-2070
DOI: https://doi.org/10.25557/2310-0435.2018.04.5-18
Keywords: neutrophils, apoptosis, cell differentiation, caspases, reactive oxygen species

Abstract

This review presented recent data on initiation, regulation, and execution of neutrophil apoptosis with participation of «death receptors», mitochondria, Bcl-2 family proteins, PI3-K (phosphatidylinositol 3-kinase), p38 MAPK (mitogen-activated protein kinase), ERK (extracellular signal regulated kinase) and JNK (c-Jun N-terminal kinase) cascades, protein kinases A, B and C, сAMP, heat shock proteins, NF-κB (nuclear factor-κB), calpains, caspases and theirs inhibitors, reactive oxygen species, and other factors. A speculative model of the apoptotic processes involvement in the regulation of neutrophil differentiation and reactivity was proposed.

Published
2019-01-23
How to Cite
Shchepetkin, I. A., Budanova, O. P., Malyshev, I. Y., & Atochin, D. N. (2019). Molecular mechanisms of neutrophil apoptosis (review). Patogenez (Pathogenesis), 16(4), 5-18. https://doi.org/10.25557/2310-0435.2018.04.5-18
Issue
Vol. 16 No. 4 (2018): Pathogenesis
Section
Reviews