Study of gangliosides and their products hydrolytic decomposition — sphingosine — in the experimental parkinsonian sindrome

  • L. M. Hovsepyan Institute of Molecular Biology, Armenian National Academy of Sciences, Hasratyan str. 7, Yerevan, 0014 Armenia
  • G. S. Kazaryan Institute of Molecular Biology, Armenian National Academy of Sciences, Hasratyan str. 7, Yerevan, 0014 Armenia
  • H. V. Zanginyan Institute of Molecular Biology, Armenian National Academy of Sciences, Hasratyan str. 7, Yerevan, 0014 Armenia
  • G. V. Zakaryan Institute of Molecular Biology, Armenian National Academy of Sciences, Hasratyan str. 7, Yerevan, 0014 Armenia
Keywords: Parkinson’s disease, gangliosides, sphingosine

Abstract

Study to determine the content of gangliosides and hydrolytic decomposition product of gangliosides —
sphingosine with experimentally induced Parkinson’s syndrome. Experimental model of Parkinson’s syndrome is
carried out daily by intraperitoneal injection of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrapiridin). As the results of
the study, in the brain of animals with the syndrome of Parkinson’s disease, a decrease of all the main factions of
gangliosides. Research has revealed the content of sphingosine increase of its content in the brain that appear to
be explained by the hydrolytic decomposition of gangliosides. Our data suggest that dysregulation of the metabolism
of gangliosides can will be a key mechanism in the pathogenesis of Parkinson’s disease.

Published
2015-06-01
How to Cite
Hovsepyan, L. M., Kazaryan, G. S., Zanginyan, H. V., & Zakaryan, G. V. (2015). Study of gangliosides and their products hydrolytic decomposition — sphingosine — in the experimental parkinsonian sindrome. Patogenez (Pathogenesis), 13(2), 47-49. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/24
Issue
Vol. 13 No. 2 (2015): Pathogenesis
Section
Original investigations