The role of parenchyma-stroma relationships in carcinogenesis of the prostate gland (review)

  • Y. A. Sutormin I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russia
  • E. Y. Kalinina I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russia
  • S. V. Popov St. Luka Clinical Hospital, St. Petersburg, Russia
  • N. M. Anichkov I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russia
  • Y. B. Cherkasova G.R. Derzhavin Tambov State University, Tambov, Russia
DOI: https://doi.org/10.25557/2310-0435.2019.02.30-37
Keywords: fibrosis, prostatitis, benign prostatic hyperplasia, prostatic intraepithelial neoplasia, prostate cancer

Abstract

The review presents current views on the role of connective tissue system in the pathogenesis of malignant growth. Based on these ideas, importance of different connective tissue cell components is discussed, specifically significance of fibroblasts and myofibroblasts, which can transform into myofibril-like cells. Participation of the cells in tumor growth, a possibility of changing their phenotypic properties and functional activity are under discussion. The role of NF-kB (nuclear factor-kB) and other molecules of intercellular communication was underlined. The authors indicated that each of the cellular components may become a target for therapy in future.

Published
2019-06-04
How to Cite
Sutormin, Y. A., Kalinina, E. Y., Popov, S. V., Anichkov, N. M., & Cherkasova, Y. B. (2019). The role of parenchyma-stroma relationships in carcinogenesis of the prostate gland (review). Patogenez (Pathogenesis), 17(2), 30-37. https://doi.org/10.25557/2310-0435.2019.02.30-37
Issue
Vol. 17 No. 2 (2019): Pathogenesis
Section
Reviews