Молекулярные маркёры острого повреждения почек (обзор)

L. D. Maltseva; D. Y. Lakomova; D. A. Morozov; N. B. Zakharova; Z. S. Manasova; O. L. Morozova

L. D. Maltseva I.M. Sechenov First Moscow State Medical University, Moscow, Russia http://orcid.org/0000-0002-4380-4522
D. Y. Lakomova V.I. Razumovsky Saratov State Medical University, Saratov, Russia http://orcid.org/0000-0002-7549-6915
D. A. Morozov I.M. Sechenov First Moscow State Medical University, Moscow, Russia http://orcid.org/0000-0002-1940-1395
N. B. Zakharova V.I. Razumovsky Saratov State Medical University, Saratov, Russia http://orcid.org/0000-0001-9410-2240
Z. S. Manasova I.M. Sechenov First Moscow State Medical University, Moscow, Russia http://orcid.org/0000-0002-3003-4362
O. L. Morozova I.M. Sechenov First Moscow State Medical University, Moscow, Russia http://orcid.org/0000-0003-2453-1319

Keywords: acute kidney injury, risk factors, diagnosis, biomarkers

Abstract

Despite the high incidence of acute kidney injury (AKI), diagnosis of its early stages is difficult due to low sensitivity and specificity of standard study methods. General clinical and biochemical blood and urine tests cannot predict the course and outcome of the disease. The aim of this review was to systematize reports of molecular markers for AKI. More than a hundred sources indexed in Scopus, MEDLINE, and Cochrane Library were analyzed. Both risk factors of AKI onset and progression and its mechanisms, and its diagnostic and predictive markers were included in the analysis. The review focused on genetic aspects of AKI onset and development and on promising methods for early diagnosis. A possibility of using molecular markers to determine the AKI severity has been demonstrated. The authors suggested that identifying specific genes and biomarkers for early stages of AKI
would improve the diagnosis and the prediction of AKI course and outcome.

Molecular markers of acute kidney injury (review)

Abstract