Assessment of human cardiovascular variability in antiorthostatic hypokinesia using the SACR-i device: new opportunities

  • A. B. Cherepov Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Research Institute of Space Medicine, All-Russia Center for Disaster Medicine “Protection” of the Federal Biomedical Agency of Russia http://orcid.org/0000-0002-3757-5292
  • I. B. Alchinova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Research Institute of Space Medicine, All-Russia Center for Disaster Medicine “Protection” of the Federal Biomedical Agency of Russia http://orcid.org/0000-0001-5294-7317
  • N. N. Khlebnikova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0002-0245-305X
  • M. A. Lebedeva Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Research Institute of Space Medicine, All-Russia Center for Disaster Medicine “Protection” of the Federal Biomedical Agency of Russia http://orcid.org/0000-0002-4601-8762
  • V. V. Pivovarov JSC Institute of Cardiology “Inkart”
  • G. K. Zaitsev JSC Institute of Cardiology “Inkart”
  • M. V. Baranov Research Institute of Space Medicine, All-Russia Center for Disaster Medicine “Protection” of the Federal Biomedical Agency of Russia http://orcid.org/0000-0002-6300-6392
  • A. V. Shpakov Institute of Biomedical Problems of the Russian Academy of Sciences
DOI: https://doi.org/10.25557/2310-0435.2022.02.70-77
Keywords: blood pressure variability; simulated microgravity; adaptation; continuous noninvasive blood pressure measurement; spiroarteriocardiorhythmograph

Abstract

A comprehensive assessment of cardiovascular variability, which includes an assessment of blood pressure (BP) variability in addition to heart rate variability, is becoming increasingly important for research under extreme conditions, i.e., space, and during modeling of space flight. The use of spiroarteriocardiorhythmographs (SACR) allows synchronous recording activity of the cardiac conduction system (ECG), BP, and respiration, as well as automatic assessment of the variability of rhythmic oscillations of heart rate and peripheral BP.

Methods. We analyzed the intensity of regulation of the human cardiovascular system during 21-day antiorthostatic hypokinesia (ANOH) using SACR devices of different generations, and we assessed their relevance for such an analysis.

Results. Measurements on the SACR device revealed a significant decrease in the overall BP variability due to prolonged, simulated microgravity. Moreover, the main contribution to these changes was made by the very low-frequency component (VLF) of systolic BP variability. It is known that specifically the VLF component of BP variability indicates a predisposition to strokes in rats and dogs, and quite possibly it has a prognostic value for assessing the risk of stroke in humans.

Conclusion. These results suggest adequate assessment of BP variability using non-invasive devices (e.g. SACR) is very important for the identification and assessment of premorbid states and can be applied to studies of adaptation to the stress and extreme conditions of space flights.

Published
2022-07-12
How to Cite
Cherepov, A. B., Alchinova, I. B., Khlebnikova, N. N., Lebedeva, M. A., Pivovarov, V. V., Zaitsev, G. K., Baranov, M. V., & Shpakov, A. V. (2022). Assessment of human cardiovascular variability in antiorthostatic hypokinesia using the SACR-i device: new opportunities. Patogenez (Pathogenesis), 20(2), 70-77. https://doi.org/10.25557/2310-0435.2022.02.70-77
Issue
Vol. 20 No. 2 (2022): Патогенез
Section
New technologies