Glutamate antibodies as regulators of mnestic functions of the CNS in neurodegenerative damages and aging of the brain

Abstract

Antibodies play an important role in the immune system. They are involved in the regulation of multistage biochemical processes and can act, on the one hand, as protective factors, and on the other hand, lead to a variety of pathological processes that occur during the antigen-antibody interaction. Of particular interest at present is the mechanism of immune regulation of the central nervous system (CNS) in the form of production of neurotransmitter autoantibodies that are an important molecular link in the interaction of these systems. As shown at present, neurotransmitter antibodies can act as endogenous protective substances involved in the regulation of the CNS in various disorders. The article focused on the role of glutamate antibodies in the regulation of mnestic functions of the CNS during aging and neurodegenerative pathology of the brain. Anti-amnesic properties of polyclonal monospecific glutamate antibodies have been shown on various experimental models of brain neurodegenerative pathology and during aging of animals.