Preeclampsia: a new look at molecular genetic markers for the prognosis and diagnosis

Abstract

Preeclampsia (PE) is one of the most common complications of pregnancy. This condition elevates the frequency of undesirable pregnancy outcomes for both the mother and the fetus and represents a serious medical and social problem. For these reasons, it is crucial to timely diagnose and predict the PE course. Although there are multiple potential clinical, biochemical and biophysical biomarkers for predicting the development of PE, none of them has been found effective or reliable so far. As preeclampsia is a multifactorial disease, genetic factors also significantly contribute to its emergence and progression. Thus, potential molecular genetic patterns involved in the PE pathogenetic pathways are being searched for. This review focuses on currently known molecular genetic biomarkers related with PE.