Ассоциация полиморфного маркера 844ins68 гена CBS с развитием и прогрессией рака молочной железы у русских женщин московского региона

A. M. Burdennyy; V. I. Loginov; V. V. Hokonova; I. V. Pronina; T. M. Zavarykina; T. P. Kazubskaya; E. A. Braga

A. M. Burdennyy Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
V. I. Loginov Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
V. V. Hokonova M.V.Lomonosov Moscow State University, Moscow, Russian Federation
I. V. Pronina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
T. M. Zavarykina N.M.Emanuel Institute for Biochemical Physics, Moscow, Russian Federation
T. P. Kazubskaya N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
E. A. Braga Institute of General Pathology and Pathophysiology, Moscow, Russian Federation

Keywords: breast cancer, glutathione-S-transferase genes, biotransformation of xenobiotics, polymorphic markers, risk of disease

Abstract

In this study the association of 844ins68 polymorphic marker in CBS gene with BC and its histological types was studied. This gene plays a very important role in homocycteine metabolism, when used in transsulphuration pathway. We found the associalion of predisposed genotype INS/INS of gene CBS with both BC and its histological types (OR = 5.44, 4.59 и 7.54, respectively). We also showed the association of this genotype with BC for women with age after 53 years old (17% against 4% in controls, OR = 5.47). It is very important to notice that we found the association of this genotype with the tumor progression in BC patients with late stage and big-sized tumors, and also in patients with metastasis and triple negative phenotype (OR = 9,14, 3,62, 3,05, 5,48, respectively). These results reflect the important role of CBS gene in BC development of Moscow region Russian females.

Association of polymorphic marker 844ins68 of CBS gene with breast cancer in females of Moscow region

Abstract