Role of RANK/RANKL/OPG system in pathogenesis of primary and metastatic bone tumors

Abstract

RANK/RANKL/OPG system — is a substantial element of bone homeostasis provides the process of bone tissue remodeling. Disorders in this system may be responsible for pathogenesis of a number of pathological states, including oncological. This review describes the mechanisms of the RANK/RANKL/OPG system, the main principles of its functioning and clinical significance. Special attention is given to the role of RANK/RANKL/OPG system in development of bone metastasis and primary bone tumors.