The influence of anti-glutamate antibodies on memory retention and neurotransmitter aminoacids level in brain structures of rats with ischemic damage of prefrontal cortex

  • F. M. Shakhova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • T. V. Davydova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • G. A. Romanova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
Keywords: rats, anti-glutamate antibodies, glutamate, photothrombosis, prefrontal cortex, hippocampus, passive avoidance reflex

Abstract

Using the rat model of bilateral photothrombosis of prefrontal cortex vessels we showed that intranasal administration of anti-glutamate antibodies one hour alter ischemic damage of brain cortex facilitates retention of passive avoidance reflex elaborated before ischemia and decreases glutamate level in hippocampus and prefrontal cortex, thus reducing neurodegenerative influence of the excitatory neurotransmitter after photothrombosis.

Published
2023-05-23
How to Cite
Shakhova, F. M., Davydova, T. V., & Romanova, G. A. (2023). The influence of anti-glutamate antibodies on memory retention and neurotransmitter aminoacids level in brain structures of rats with ischemic damage of prefrontal cortex. Patogenez (Pathogenesis), 11(3), 49-53. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/662
Issue
Vol. 11 No. 3 (2013): Патогенез
Section
Original investigations