The role of antibodies to GABA and glutamate in pathogenesis of neuropathic pain syndrome

  • S. I. Igon'kina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • V. N. Grafova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • V. S. Smirnova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • L. A. Vetrile Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • I. A. Zaharova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • V. A. Evseev Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • M. L. Kukushkin Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
Keywords: antibodies to GABA, antibodies to glutamate, neuropathic pain syndrome, spontaneous pain paroxysms, allodynia

Abstract

The role of the antibodies to inhibitory neurotransmitter GABA and to excitatory neurotransmitter glutamate in pathogenesis of neuropathic pain syndrome on models of neuropathic pain syndrome was studied. It was shown that the development of experimental neuropathic pain syndrome is accompanied with induction of autoantibodies to glutamate and GABA. It was established that the antibodies to inhibitory neurotransmitter GABA have a pronociceptive effect and the antibodies to excitatory neurotransmitter glutamate have an antinociceptive effect.

Published
2023-05-27
How to Cite
Igon’kina, S. I., Grafova, V. N., Smirnova, V. S., Vetrile, L. A., Zaharova, I. A., Evseev, V. A., & Kukushkin, M. L. (2023). The role of antibodies to GABA and glutamate in pathogenesis of neuropathic pain syndrome. Patogenez (Pathogenesis), 10(4), 36-40. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/692
Issue
Vol. 10 No. 4 (2012): Патогенез
Section
Original investigations