The activation of latent herpetic infection in stroke (Experimental Investigation)

  • A. E. Kulchikov Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • S. G. Morozov Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • E. A. Grinenko Institute of Neurosurgey named acad. N.N. Burdenko RAMS, Moscow, Russian Federation
Keywords: hemorrhagic stroke, herpes simplex virus, encephalitis

Abstract

The purpose of the investigation was to study a possibility of latent virus infection activation in mouse brain by modeling hemorrhagic stroke. The acute intracerebral hemorrhagic stroke was evoked in capsula interna in accordance with original technology. For experimental viral meningo encephalitis white mice infected by subletal dose of herpes simplex viruses. DNA of the herpes simplex virus type I was detected by PCR-based assay in blood and in brain tissue of experimental animals as well as inflammatory changes of the brain after acute hemorrhagic stroke which suggests that persistent herpes simplex virus type I was activated. Obtained data show that in the acute period of experimental hemorrhagic stroke activation of dormant infections in the form of encephalitis may occur in the white mice brain. Considering the results obtained permits to improve the monitoring and treatment of hemorrhagic stroke.

Published
2023-05-31
How to Cite
Kulchikov, A. E., Morozov, S. G., & Grinenko, E. A. (2023). The activation of latent herpetic infection in stroke (Experimental Investigation). Patogenez (Pathogenesis), 10(2), 39-43. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/709
Issue
Vol. 10 No. 2 (2012): Патогенез
Section
Original investigations