Autoregulation of cerebral blood flow in normal and during postischemic hypoperfusion

Abstract

Objective: to study the interaction between myogenic link of autoregulation of cerebral blood flow and other factors of modulation of vessel’s tone in control and during postishemic hypoperfusion.

Subjects and methods. Rat, anesthetized with chloralhydrate, were equipped with closed cranial window and pial arteriolar diameter was measured before and alter hemorrhage. Myogenic reaction (wall tension) calculated by Laplace low. Microcirculation was explored by laser Doppler flowmetry.

Results. The myogenic reaction is the leading factor of autoregulation of cerebral blood flow in control. Postischemic hypoperfusion is conditioned by endothelial disfunction. The myogenic reaction is the leading factor of autoregulation of cerebral blood flow during the hypoperfusion.

Conclusion. Autoregulation is realized by myogenic mechanism. Modulated factors (neurogenic, metabolic, endothelial) change a vessel’s tension and a value of cerebral blood flow. It is the diagonal shift of the autoregulation curve.