The features of blood supply to the rat medulla during pathological periodic apneustic respiration provoked by sodium hydroxybutyrate

  • L. N. Tikhomirova Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-3601-1401
  • D. D. Matsievsky Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-4368-8832
  • S. V. Revenko Institute of Experimental Cardiology of the National Medical Research Center of Cardiology, Moscow, Russia
  • I. A. Tarakanov Institute of General Pathology and Pathophysiology, Moscow, Russia
Keywords: periodic respiration, cerebral circulation, hydroxybutyrate, rat

Abstract

The model of periodic apneustic respiration provoked by sodium hydroxybutyrate was used in acute experiments on anaesthetized mongrel male albino rats to examine the blood supply to the region of respiratory center in the brain stem. The development of periodic pathological respiration was associated with specific periodic oscillations of 1) blood flow in the brain stem microvasculature and 2) oxygenation of the nervous tissue following the respiration rhythm. Under these conditions, both blood supply to and venous outflow from the brain were augmented. The study suggested that the characteristic oscillations of blood supply to the brain at the respiration rhythm emerge not only in the brain stem but also in other cerebral regions. Probably, they are caused by oscillations of venous outflow induced by the suction effect of the chest cavity during inspiration.

Published
2018-12-11
How to Cite
Tikhomirova, L. N., Matsievsky, D. D., Revenko, S. V., & Tarakanov, I. A. (2018). The features of blood supply to the rat medulla during pathological periodic apneustic respiration provoked by sodium hydroxybutyrate. Patogenez (Pathogenesis), 16(4), 119-123. https://doi.org/10.25557/2310-0435.2018.04.119-123
Section
Brief reports