The role of NF-_B and ð38-mediated signaling pathways in hematopoiesis regulation under immobilization stress

Authors

  • A M Dygay FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • V V Zhdanov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • L A Miroshnichenko FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E V Udut FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • G N Zyuz`kov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • T Y Khrichkova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E V Simanina FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • L A Stavrova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • A V Chaikovskiy FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • V I Agafonov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3

Keywords:

signaling pathways, transcriptional factor NF-kB, p38 mitogen-activated protein kinase, immobilization, granulocytic colony-stimulating factor

Abstract

Under the conditions of immobilization stress was found participation protein kinase p38 in the production of granulocyte colony-stimulating factor by hematopoietic microenvironment cells. The observed increased colony- forming ability in the absence of maturation processes elements of clonogenic granulocytic lineage bone marrow is implemented with the participation of NF-kB/IKK-dependent signaling and p38MAPK signaling pathway. It is shown important role of p38MAPK in the regulation of granulocytopoiesis, but not erythropoiesis.

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Published

2015-11-30

Issue

Vol. 13 No. 3 (2015): Pathogenesis

Section

Original investigations

How to Cite

1.
Dygay AM, Zhdanov VV, Miroshnichenko LA, et al. The role of NF-_B and ð38-mediated signaling pathways in hematopoiesis regulation under immobilization stress. Патогенез. 2015;13(3):26-30. Accessed April 30, 2026. https://pathogenesis.pro/index.php/pathogenesis/article/view/30

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