The effect adrenoceptor agonists on product cytokines in development immune response

Authors

  • E Yu Sherstoboev FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • O G Shitikova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • M G Danilets FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • N V Masnaya FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E S Trofimova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • A A Ligacheva FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3

Keywords:

alpha- and beta-adrenoagonists, cytokines, humoral immune response

Abstract

The influence of alpha- and beta-adrenoceptor agonists on cytokine production by splenocytes of mice-hybrids F1 (CBAxC57Bl/6) in the development of humoral immune response was studied. It was shown that the use of phenylephrine inhibited of TNF-α and IL-1β production, while there was the increase of IL-2, IL-6, IL-10, and IFN-γ secretion after immunization. The isoproterenol administration in immunized mice resulted in the decrease of IL-2, IL-6 and IL-10 production in early terms after immunization, but it was observed the increase of TNF-α, IL-1β and IFN-γ production.

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Published

2015-09-30

Issue

Vol. 13 No. 3 (2015): Pathogenesis

Section

Original investigations

How to Cite

1.
Sherstoboev EY, Shitikova OG, Danilets MG, Masnaya NV, Trofimova ES, Ligacheva AA. The effect adrenoceptor agonists on product cytokines in development immune response. Патогенез. 2015;13(3):45-49. Accessed April 30, 2026. https://pathogenesis.pro/index.php/pathogenesis/article/view/33