Some neuroimmune mechanisms in pathogenesis of epilepsy

Abstract

The review is devoted to the analysis of neuroimmune interactions in pathogenesis of epilepsy. The results of studies showing the important role of neuroimmune processes in the onset of the disease, stage of pre-clinical and clinical course. The pathogenetic role of pro-inflammatory cytokines, antibodies to antigens of nervous tissue and neurotransmitters, such as GABA, glulamate, dopamine and serolonin in pathogenesis of epilepsy is discussed. The data presented demonstrate the need for determining the immune status of patients with epilepsy to determine the severity of the disease and the purpose of adequate treatment. The authors analyze their own data of anticonvulsant activity of antibodies to glutamate and opposite proconvulsant effect of antibodies to GABA on different models of epileptic activity.