Role of RANK/RANKL/OPG system in pathogenesis of primary and metastatic bone tumors

Authors

  • N. E. Kushlinskiy N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • Yu. A. Timofeev N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Keywords:

RANK, RANKL, OPG, sarcoma, metastasis, bone tumors, homeostasis

Abstract

RANK/RANKL/OPG system — is a substantial element of bone homeostasis provides the process of bone tissue remodeling. Disorders in this system may be responsible for pathogenesis of a number of pathological states, including oncological. This review describes the mechanisms of the RANK/RANKL/OPG system, the main principles of its functioning and clinical significance. Special attention is given to the role of RANK/RANKL/OPG system in development of bone metastasis and primary bone tumors.

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Published

2023-05-17

Issue

Vol. 11 No. 4 (2013): Патогенез

Section

Reviews

How to Cite

1.
Kushlinskiy NE, Timofeev YA. Role of RANK/RANKL/OPG system in pathogenesis of primary and metastatic bone tumors. Патогенез. 2023;11(4):9-15. Accessed May 20, 2026. https://pathogenesis.pro/index.php/pathogenesis/article/view/647