Magnetic sorbents in extracorporal therapy in patients with systemic lupus erythematosus and antiphospholipid syndrome

Abstract

The aim of the study is to investigate the effectiveness of a novel magnetic immobilized antigen sorbents in sera from systemic lupus erythematosus (SLE) patients during antiphospholipid syndrome (APS) therapy. Methods. The immune sorption of the anti-cardiolipin antibody-containing sera from 63 SLE patients with APS was performed in a column equipped with a magnet in in vitro conditions. Results. The high efficiency of antibody sorption to cardiolipin using a developed magnetic sorbent has been shown in comparison with well-known techniques. In addition, a novel sorbent caused only slight injuries of blood cells and possessed a low nonspecific sorption. As a result, the concentration of serum anti-cardiolipin antibodies was reliably decreased. Conclusion. Due to removal of high pathogenic antibodies from the blood flow, an extracorporeal sorption of cardiolipin antibodies may be a promising treatment of SLE patients with APS.