Endothelial dysfunction in the pathogenesis of ischemic stroke: aspects of statin therapy

Authors

  • A. L. Khokhlov State budgetary educational authority "Yaroslavl State Medical University", Yaroslavl, Russia
  • A. Yu. Malygin State healthcare au thor ity of Yaroslavl Region "Clinical Hospital No.8", Yaroslavl, Russia
  • Yu. E. Melnikova State healthcare au thor ity of Yaroslavl Region "Clinical Hospital No.8", Yaroslavl, Russia

Keywords:

ischemic stroke, endothelial dysfunction, cardiovascular events, HMG-CoA reductase inhibitors

Abstract

A 24-months study was conducted to assess efficacy of early and long-term statins administration in treatment of acute hemispheric ischemic stroke. During the first stage were analyzed parameters: lethality, incidence of recurrent cardiovascular events, grade of endothelial dysfunction and simvastatin safety. During the second stage, dynamic comparative analysis of study parameters depending on the drug (hydroxymethylglutaryl-coenzyme A reductase group) and treatment duration was performed.

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Published

2017-12-02

Issue

Vol. 14 No. 3 (2016): Pathogenesis

Section

Original investigations

How to Cite

1.
Khokhlov AL, Malygin AY, Melnikova YE. Endothelial dysfunction in the pathogenesis of ischemic stroke: aspects of statin therapy. Патогенез. 2017;14(3):58-64. Accessed April 8, 2026. https://pathogenesis.pro/index.php/pathogenesis/article/view/76