Differences in the Recovery Period of Myocardial Contractility in Hibernation and Stunned Syndromes

Abstract

Diseases of the cardiovascular system continue to occupy a leading place in the structure of mortality of the population. The main cause of deaths at the moment is coronary heart disease (CHD), the prevalence of which among the working-age population continues to increase. Progress in the diagnosis and treatment of coronary heart disease made it possible to study in more detail the pathogenetic changes occurring in the ischemic myocardium and allowed us to identify areas that had impaired contractile function, but retained vitality and metabolic activity. In further studies, it was found that some of these cardiomyocytes regained their contractility over time. This made it possible to change the modern view of the structure of this disease and introduce the concept of "new ischemic syndromes", which currently include hibernation and stunning. The article considers the opinions of domestic and foreign authors on the mechanisms and timing of myocardial recovery in these syndromes. The dependence of the nature of the changes on the frequency and volume of hypoperfusion was studied, a correlation was noted between the severity of the injuries and the recovery period of the myocardium, which will allow practitioners in the future to clinically more clearly separate these ischemic syndromes and better predict the timing of the return of cardiac activity to a normal level.