The role of heat shock proteins in microgravity and spaceflights

Abstract

In recent years, scientists have been actively researching the effects of microgravity on the human body during long-term space missions. The research has found that a prolonged stay in outer space can lead to a number of adverse consequences, such as problems with the musculoskeletal and cardiovascular systems, as well as a decrease in immunity. One promising approach to mitigate these effects is the study of heat shock proteins (HSP), which are believed to play a protective role under stress conditions like those experienced during space flights. Experiments have shown that these proteins become more active in cells when subjected to microgravity conditions. This suggests their potential use in studying stress responses in space. In the future, scientific research may lead to the development of drugs or other ways to modulate the function of heat shock proteins, helping to maintain astronauts' health during prolonged space travel. This review aims to evaluate current knowledge about the effects of exposure to adverse conditions, such as microgravity, on the human body, with a focus on the role of heat shock proteins.