Effect of complex compounds of methyl derivatives of 5-hydroxyuracil with succinic acid on the antioxidant system and the morpho-functional state of the liver of old rats exposed to carbon tetrachloride

Abstract

The influence of two new complex compounds of methyl derivatives of 5-hydroxyuracil with succinic acid on
the antioxidant system and morpho-functional state of the liver of old rats exposed to carbon tetrachloride has been studied experimentally. The aim was to study the influence of complex compounds — 5-hydroxy-1,3,6-trimethyluracil succinate (1) and 5-hydroxy-3,6-dimethyluracil succinate (2) — on the processes of free radical oxidation, antioxidant system regulating these processes and morpho-functional state of the liver of old rats exposed to carbon tetrachloride. Results. Complex Compounds 1 and 2 used prophylactically in old rats (50 mg/kg three times/day x 4 intraperitoneally, then 50 mg/kg once/per day x 3 intraperitoneally) have been shown to limit necrosogenic effects of TCR (2 g/kg/day><4 subcutaneously), to preserve partially functional — metabolic activity due to favorable effects on enzymes (AST, alkaline phosphatase), total blood bilirubin and cholesterol and also due to partial normalization of POL/AOS imbalance. According to most indicators, Compound 1 turns out to be more effective and comparable to the effect of the silymin hepatoprotector. Conclusion. The Compound 1 reduced the intensity and prevalence of dystrophic and necrotic processes of cellular reactions of the liver tissues in old rats and limited significantly the severity of TCR hepatotoxicity due to a corrective effect on glutathione and enzymatic antioxidant defense system.