Analysis of expression alterations of RASSF1A, SEMA3B, RHOA, GPX1, RAR-beta, and NKIRAS1 genes in clear cell carcinoma

  • E. A. Braga Institute of General Pathology and Pathophysiology, Moscow, Russia; Medical Genetics Research Center, Moscow, Russia
  • I. V. Pronina Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-0423-7801
  • V. I. Loginov Institute of General Pathology and Pathophysiology, Moscow, Russia; Medical Genetics Research Center, Moscow, Russia http://orcid.org/0000-0003-2668-8096
  • T. P. Kazubskaya N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
DOI: https://doi.org/10.25557/2310-0435.2018.04.141-143
Keywords: clear cell carcinoma (ccRCC – clear cell renal cell carcinoma), gene expression level, chromosome 3 genes

Abstract

The genes of the short arm of human chromosome 3 in epithelial tumors are subject to frequent deletions, amplifications, mutations, and methylation, which affects their expression. We studied the expression of 6 genes from critical regions of the human chromosome 3 in clear cell renal cell carcinoma, SEMA3B, RASSF1A, RAR-beta2, GPX1, RHOA, and NKIRAS1. For the first time, the dependence of changes in the mRNA content of these genes on the clinical stage of cancer was studied. Analysis of changes in the expression of the NKIRAS1 gene in clear cell renal cell carcinoma was performed for the first time. The obtained data may be useful for selection of prognostic markers of kidney cancer.

Published
2019-01-25
How to Cite
Braga, E. A., Pronina, I. V., Loginov, V. I., & Kazubskaya, T. P. (2019). Analysis of expression alterations of RASSF1A, SEMA3B, RHOA, GPX1, RAR-beta, and NKIRAS1 genes in clear cell carcinoma. Patogenez (Pathogenesis), 16(4), 141-143. https://doi.org/10.25557/2310-0435.2018.04.141-143
Issue
Vol. 16 No. 4 (2018): Pathogenesis
Section
Brief reports