Mitochondria and the innate immune response. A review

Abstract

This review is devoted to mitochondrial dysfunction, which is associated with many pathologies. Classic role of mitochondria in a wide range of diseases commonly associated with their ability to regulate cellular metabolism and cell death. However, in the course of ongoing studies appear fresh data about the important role of mitochondria as the initiators and performers of the innate immune response. This new paradigm corresponds to the current dogma, according to which the molecules on the surface or inside the mitochondria, may act as immune regulators in response to cellular stress or pathogens and may be responsible for the initiation of new or exacerbation of chronic in flammatory processes observed in many diseases.