Epileptic reaction in rats induced by sharp reduction of atmospheric air pressure

  • R. A. Kopaladze Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • A. M. Dudchenko Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • A. A. Kubatiev Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
Keywords: rats, hypobaric epileptic reaction, system of evaluation, mexidol, carbamazepine

Abstract

It is shown that the «rise» of rats at a speed of 50 m/s at the «height» of 5000 meters in the chamber (decompression) in 5% o f rats causes a sharp motor agitation, culminating in pronounced clonic-tonic epileptic seizure. The developed method of selection of rats susceptible to decompression, characterized are all parameters of epileplic reaclion and forms of seizure, the syslem for assessing the severity of hypobaric epiieplic reaclion and anticonvulsant activity of drugs is worked out

Published
2023-05-26
How to Cite
Kopaladze, R. A., Dudchenko, A. M., & Kubatiev, A. A. (2023). Epileptic reaction in rats induced by sharp reduction of atmospheric air pressure. Patogenez (Pathogenesis), 12(2), 61-66. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/629
Issue
Vol. 12 No. 2 (2014): Патогенез
Section
Original investigations