Correction of pathological periodic respiration with Mexidol in rats

Abstract

A possibility of using the Mexidol metabolic therapy for correction of hydroxybutyrate-provoked periodic pathological respiration was evaluated in acute experiments on anesthetized white mongrel male rats. Mexidol at doses of 40—200 mg/kg dose-dependently normalized the respiratory rhythm. Mexidol at doses of 100—200 mg/kg maintained the normal, rhythmic respiration for several hours. Therefore, Mexidol is an effective drug for correction of the periodic pathological breathing with arrest in the quiet expiratory phase, which normalizes generation of the respiratory rhythm for several hours.