Lipopolysaccharide-binding protein and sCD14 in patients with type 1 diabetes mellitus and diabetic nephropathy

Authors

  • I.A. Yatskov Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0000-0002-5486-7262
  • V.A. Beloglazov Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0000-0001-9640-754X
  • E.S. Ageeva Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0000-0003-4590-3580
  • I.N. Repinskaya Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0000-0001-6200-1699
  • E.R. Zagidullina Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0009-0005-9693-5461
  • V.B. Kaliberdenko Order of the Red Banner of Labor S.I. Georgievsky Medical Institute of the V.I. Vernadsky Crimean Federal University, Simferopol, Russian Federation https://orcid.org/0000-0003-1693-3190

DOI:

https://doi.org/10.48612/path/2310-0435.2026.01.64-69

Keywords:

type 1 diabetes mellitus, diabetic nephropathy, lipopolysaccharide, LBP, sCD14, endotoxemia, chronic endotoxin aggression, endotoxin tolerance

Abstract

Diabetic nephropathy (DN) is one of the most severe complications of type 1 diabetes mellitus (DM1), the pathogenesis of which is associated with chronic inflammation and endotoxinemia. Proteins such as lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14), which are obligatory participants in the LPS interaction with Toll-like receptor 4 (TLR4), play a key role in the realization of the biological effects of lipopolysaccharide (LPS). However, their status in patients with DM1 and DN remains poorly understood.

Aim. To evaluate the levels of LBP and sCD14 in patients with DM1, depending on the presence of diabetic nephropathy.

Materials and methods. The study included 92 patients with DM1, divided into two groups: DM1 without DN (n = 19) and DM1 with DN (n = 73). The levels of LBP, sCD14, CRP, HbA1c, microalbuminuria, urea and creatinine were determined.

Results. Patients with DN showed a significant decrease in the level of sCD14 (8.85 (7.0–10.5) pg/ml vs. 15.6 (10.5–53.2) pg/ml; p=0.012). The HbA1c level in the DN group was lower (8.15% (7.11–9.55) vs. 11.2% (7.6–11.8); p=0.038). The level of LBP did not significantly differ between the groups (p=0,177).

Conclusion. A decrease in sCD14 levels is associated with the development of DN in patients with DM1. However, the levels of CRP and LBP did not differ significantly between the groups. This finding may indicate the development of endotoxin tolerance against the background of low-intensity LPS-induced inflammation, which may subsequently be accompanied by the progression of vascular complications.

Published

2026-03-02

Issue

Vol. 24 No. 1 (2026): Pathogenesis

Section

Clinical researches

How to Cite

Lipopolysaccharide-binding protein and sCD14 in patients with type 1 diabetes mellitus and diabetic nephropathy. (2026). Patogenez (Pathogenesis), 24(1), 64-69. https://doi.org/10.48612/path/2310-0435.2026.01.64-69

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