Biochemical analysis of the blood in nondiabetic rats after per os treatment with vanadium-containing substances

  • V. O. Erkudov Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
  • A. P. Pugovkin Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
  • Y. V. Bagrina Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
  • I. V. Sergeev Pavlov Insitut of Physiology of the Russian Academy of Science, Saint-Petersburg, Russia
Keywords: rat, vanadium, hypoglycemia, alaninaminotransferase, aspartateaminotransferase

Abstract

The aim of the study was to reveal hypoglycemic and toxic effects of chronic peroral treatment of nondiabetic
rats with compounds containing vanadilsulphate, or sodium metvadanate or vanadium tartrate. In the first and second groups the treatment was followed by hypoglycemia, total plasma protein, albumin and carbamide concentration together with decrease of alaninaminotransferase (ALT) aspartateaminotransferase (AST) activity. None of these effects were observed after treatment with vanadium tartrate. Possible mechanism of hypoglycemic action of vanadium-containing compounds and their pharmacological application in hyperglycemia treatment are discussed.

Published
2017-05-28
How to Cite
Erkudov, V. O., Pugovkin, A. P., Bagrina, Y. V., & Sergeev, I. V. (2017). Biochemical analysis of the blood in nondiabetic rats after per os treatment with vanadium-containing substances. Patogenez (Pathogenesis), 15(1), 48-53. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/111
Issue
Vol. 15 No. 1 (2017): Pathogenesis
Section
Experimental researches