Клеточные микрофлюидные технологии для биомоделирования патологических процессов

A. N. Mylnikova; D. V. Kolesov; A. A. Moskovtsev; A. A. Sokolovskaya; V. A. Yurkiv; A. A. Kubatiev

A. N. Mylnikova Institute of General Pathology and Pathophysiology, Moscow, Russia; D.I. Mendeleev Russian University of Chemical Technology, Moscow, Russia
D. V. Kolesov Institute of General Pathology and Pathophysiology, Moscow, Russia
A. A. Moskovtsev Institute of General Pathology and Pathophysiology, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia
A. A. Sokolovskaya Institute of General Pathology and Pathophysiology, Moscow, Russia https://orcid.org/0000-0002-0112-2734
V. A. Yurkiv Central Research Institute of Epidemiology, Moscow, Russia
A. A. Kubatiev Institute of General Pathology and Pathophysiology, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia

Keywords: microfluidics, biomodeling, cell technologies

Abstract

Significant technological progress has brought new approaches to cell biology. Using microfluidic technologies has opened new opportunities for cultivation, analysis, and manipulation of both individual cells and their populations. The basis of the new technology is a microfluidic chip, a miniature device containing a sys tem of micro- and nanochannels, cavities, membranes, and other elements. The precise control of spatial arrangement of cells and their microenvironment opens new prospects for in vitro biomodeling of functional elements of organs and tissues. This review shows examples for construction and application of such three-dimensional microfluidic cellular models for analysis of physiological and pathological processes. Particular attention is paid to the influence of cellular microenvironment on cell functioning.

Cell microfluidics technologies for biomodeling of pathological processes

Abstract