Cell cultures of human malignant tumors in development of new anticancer therapies

  • A. N. Chernov V.A. Almazov National Medical Research Center, St. Petersburg, Russia
  • E. P. Barantsevich V.A. Almazov National Medical Research Center, St. Petersburg, Russia
  • E. S. Galimova V.A. Almazov National Medical Research Center, St. Petersburg, Russia
  • M. M. Galagudza V.A. Almazov National Medical Research Center, St. Petersburg, Russia
Keywords: cancer, cell culture, anticancer drug efficacy, in vitro screening, panel of cancer cell lines, two-dimensional (2D) model of cell culture, three-dimensional (3D) model of cell culture

Abstract

Current effective preclinical screening of new anticancer chemotherapies and biological medicines requires cancer cell culture models. Such models include primary cell cultures and human tumor cell lines cultured in two-dimensional (2D) and three-dimensional (3D) systems. This review discussed different aspects of using human tumor cell culture models and their relevance for studying efficacy of antitumor drugs.

Published
2017-11-17
How to Cite
Chernov, A. N., Barantsevich, E. P., Galimova, E. S., & Galagudza, M. M. (2017). Cell cultures of human malignant tumors in development of new anticancer therapies. Patogenez (Pathogenesis), 15(4), 13-23. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/141
Issue
Vol. 15 No. 4 (2017): Pathogenesis
Section
Reviews