Age dependence of respiratory rhythm generation disturbaces in rats after hydrohybutyrate administration

  • L. N. Tikhomirova FSBSI «Institute of general pathology and pathophysiology», Russia1, 25315, Moscow, Baltiyskaya st., 8
  • I. A. Tarakanov FSBSI «Institute of general pathology and pathophysiology», Russia1, 25315, Moscow, Baltiyskaya st., 8
Keywords: pathological breathing, respiratory rhythm, age, hydrohybutirate, rat

Abstract

In experiments on pentobarbital anesthetized outbred white rats of both sexes the resistance of respiratory
rhythm generation was studied by means of activation GHBA- and GABAb receptors with hydroxybutyrate. It was
found that the probability of occurrence of pathological respiratory periodic arrests in the phase of quiet expiration
caused by hydroxybutyrate administration depends on the age and increased in older rats. We can assume that
the described phenomenon may be included in the pathogenesis mechanism of sleep apnea, when the brain
GABAergic system is activated significantly by and which is especially pronounced in middle-aged and older patients.

Published
2015-06-01
How to Cite
Tikhomirova, L. N., & Tarakanov, I. A. (2015). Age dependence of respiratory rhythm generation disturbaces in rats after hydrohybutyrate administration. Patogenez (Pathogenesis), 13(2), 23-26. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/18
Issue
Vol. 13 No. 2 (2015): Pathogenesis
Section
Original investigations