Differential detection of autoantibodies to Aβ25-35 in patients with different duration of Alzheimer’s disease course
Abstract
The pathology of a number of neurodegenerative diseases such as Alzheimer’s disease is associated with the aggregation of certain proteins and peptides, leading to the deposition of amyloid in the brain. It is shown that immunological factors also play a significant role in the development of these diseases. The purpose of this work was a comparative determination of the level of autoantibodies to prefibrillary (oligomers) Aβ25-35 structures in the blood serum of patients with different duration of the course of the diagnosed Alzheimer’s disease compared with age control. Methods. The level of antibodies to oligomers Aβ25-35 was detected using enzyme-linked immunosorbent assay and expressed in titers. Results. It was found that the level of autoantibodies to Aβ25-35 oligomers varies differentially and depends on the duration of the disease. Thus, with a 5-year duration of the disease, the level of autoantibodies to oligomers Aβ25-35 is 2 times higher than in the initial stages of the disease (1 year) and the age control hundreds of times. It is noted that with a disease duration of more than 10 years (15—20 years), the level of antibodies to Aβ25-35 practically does not change, which is probably explained by the formation of immune complexes. The data obtained may be of practical interest in the development of correction schemes for Alzheimer’s disease, taking into account immune disorders.
