Migraine genetics: Associative studies

  • J. E. Azimova Institute of General Pathology and Pathophysiology, Moscow, Russia; LLC University Headache Hospital, Moscow, Russia
  • N. Kondratieva M.V. Lomonosov Moscow State University, Moscow, Russia
  • E. A. Klimov M.V. Lomonosov Moscow State University, Moscow, Russia
  • M. L. Kukhushkin Institute of General Pathology and Pathophysiology, Moscow, Russia
DOI: https://doi.org/10.25557/2310-0435.2018.03.154-156
Keywords: migraine, genetics, polymorphisms

Abstract

The article focused on analysis of currently available reports on genetic polymorphisms in migraine. The migraine candidate genes were grouped into four functional families: genes of the nervous system, genes of the cardiovascular system, hormonal genes, and inflammatory genes. Among the nervous system genes, the genes encoding the structure and functional activity of potassium channels are of a special significance. Of the greatest interest are the cardiovascular system genes, which increase the risk of both migraine and comorbid cardiovascular diseases. Among the endocrine system genes, polymorphisms of the type 1 estrogen receptor gene play a role in the pathogenesis of migraine. Positive associations with migraine were found for in flammatory genes of cyclooxygenase 2, the main histocompatibility complex HLA-DRB1, lymphotoxin alpha, and tumor necrosis factors alpha and beta.

Published
2018-12-31
How to Cite
Azimova, J. E., Kondratieva, N., Klimov, E. A., & Kukhushkin, M. L. (2018). Migraine genetics: Associative studies. Patogenez (Pathogenesis), 16(3), 154-156. https://doi.org/10.25557/2310-0435.2018.03.154-156
Issue
Vol. 16 No. 3 (2018): Pathogenesis
Section
Brief reports