Особенности исследования функций тромбоцитов в условиях микрогравитации

E.A. Sergeeva; A.A. Metelkin; A.V. Marchenkova; A.N. Protsenko; A.A. Sokolovskaya

doi:10.48612/path/2310-0435.2025.01.17-24

E.A. Sergeeva Institute of General Pathology and Pathophysiology, Moscow, Russian Federation https://orcid.org/0000-0003-4690-6900
A.A. Metelkin Institute of General Pathology and Pathophysiology, Moscow, Russian Federation https://orcid.org/0000-0001-8018-4978
A.V. Marchenkova D.I. Mendeleev Russian University of Chemical Technology, Moscow, Russian Federation https://orcid.org/0009-0009-5268-6941
A.N. Protsenko N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation https://orcid.org/0009-0003-7468-998X
A.A. Sokolovskaya Institute of General Pathology and Pathophysiology, Moscow, Russian Federation https://orcid.org/0000-0002-0112-2734

DOI: https://doi.org/10.48612/path/2310-0435.2025.01.17-24

Keywords: simulated microgravity, space biotechnology, platelets, cell physiology

Abstract

Microgravity is known to cause hemorrhagic complications by decreasing platelet counts and impairing their function. Inhibition of migration, delayed cell cycle progression, followed by growth retardation, and disruption of platelet hematopoietic progenitor differentiation patterns have been observed under simulated microgravity conditions, which may explain changes in platelet counts. This review examines various experimental models used to simulate microgravity, as well as methods and results of studying platelet functions under altered gravity conditions. In addition, data are presented showing that the use of platelet-rich plasma enhances tissue regeneration and accelerates wound healing.

Platelet function research under microgravity conditions

Abstract