Pathogenetic relationship of some indices of central hemodynamics and organ blood flow with duration of artificial ventilation in extremely premature infants

Abstract

Relevance: Extremely premature infants may have particularly long stays in the intensive care unit, one of the main reasons being the patient's dependence on artificial ventilation.

Aim. To determine the pathogenetic factors that influence the prolonged stay of extremely premature infants on artificial ventilation.

Methods. This is a retrospective study of 24 extremely preterm infants in the intensive care unit. The newborns were examined during the first month of life. Six periods were allocated for the study. The relationship between regional and systemic hemodynamic parameters and oxygen demand was assessed. The influence of these indicators on patients' dependence on artificial ventilation was also assessed.

Results. A relationship has been established between long-term artificial ventilation of the lungs and oxygen dependence, lower indicators of systemic hemodynamics, worse absorption of enteral nutrition and a higher rate of diuresis. There is a pathogenetic relationship between the immaturity of functional regulatory mechanisms, the assimilation of enteral nutrition on the one hand, and the need for infusion and ventilation support on the other. As a result, pathogenetic vicious circles are formed, which worsen the condition of patients.

Conclusion. Both respiratory failure and hemodynamic instability may influence the duration of mechanical ventilation in extremely preterm infants.