The role of functional polymorphysms C677T and A1298C of MTHFR gene in breast cancer pathogenesis of Russian females

  • A M Бурденный Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315
  • V I Loginov Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315
  • T P Kazubskaya Blokhin Cancer Research Center, 115478 Moscow
  • E A Braga Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315
Keywords: breast cancer, MTHFR gene, polymorphisms

Abstract

The folic acid metabolism is the most important biochemical cell process. That’s why the great interest for different molecular-genetic disorders in folate metabolism genes is at stake in studying role of them in imbalance of DNA methylation, synthesis and reparation processes. The most valuable in this case is MTHFR gene. In the present paper we studied association of two polymorphisms C677T è A1298C of MTHFR gene with its histological subtypes included. We showed a positive association of both polymorphisms with both breast cancer itself and its lobular subtype. We also revealed association of both studied polymorphisms in breast cancer progression. These results reported of the important role of MTHFR gene breast cancer pathogenesis in Russian females.

Published
2015-09-30
How to Cite
БурденныйA. M., Loginov, V. I., Kazubskaya, T. P., & Braga, E. A. (2015). The role of functional polymorphysms C677T and A1298C of MTHFR gene in breast cancer pathogenesis of Russian females. Patogenez (Pathogenesis), 13(3), 50-55. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/34
Issue
Vol. 13 No. 3 (2015): Pathogenesis
Section
Original investigations