Обзор механизмов действия и свойств гепатопротекторных препаратов

E. V. Kardash; E. M. Grigorieva; A. G. Еmelyanova; S. A. Tarasov

doi:10.25557/2310-0435.2020.02.36-44

E. V. Kardash Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0001-8005-4209
E. M. Grigorieva Institute of Protein Research of the Russian Academy of Sciences, Pushchino of the Moscow Region, Russia http://orcid.org/0000-0001-7974-9310
A. G. Еmelyanova Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-0832-9551
S. A. Tarasov Institute of General Pathology and Pathophysiology, Moscow, Russia http://orcid.org/0000-0002-6650-6958

DOI: https://doi.org/10.25557/2310-0435.2020.02.36-44

Keywords: hepatoprotective properties, hepatic disorders, antioxidant activity

Abstract

Medical practice quite often requires simultaneous administration of several drugs. Sometimes it is impossible due to their hepatotoxicity; therefore, urgent tasks of pharmacology include searching for and developing new drugs as well as optimizing already existing products in order to reduce side effects during their administration. This review focused on pharmacological drugs of the hepatoprotector class and their mechanisms of action and evaluated the prospects of searching for new medicines. In conclusion, drugs containing essential phospholipids and those improving recirculation and removal of bile acids are currently the most popular agents in clinical practice. Mechanisms of action of these drugs are theoretically justified and there is a prospect for building an evidence base for them by randomized clinical trials and meta-analyses.

Review of properties and mechanisms of action of hepatoprotective drugs

Abstract