Лекарственные пептидные препараты в аспекте доказательной медицины

V. Kh. Khavinson; I. G. Popovich; G. A. Ryzhak; G. L. Safarova; E. A. Vershinina

V. Kh. Khavinson Research Center, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia; I.P.Pavlov Institute of Physiology, St. Petersburg, Russia http://orcid.org/0000-0001-7547-7725
I. G. Popovich Research Center, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia; N.N.Petrov National Medical Research Center of Oncology, St. Petersburg, Russia http://orcid.org/0000-0002-9937-025X
G. A. Ryzhak Research Center, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia http://orcid.org/0000-0003-2536-1438
G. L. Safarova Institute of Regional Economics Problems of the Russian Academy of Sciences, St. Petersburg, Russia http://orcid.org/0000-0003-0289-7977
E. A. Vershinina I.P.Pavlov Institute of Physiology, St. Petersburg, Russia; Institute of Regional Economics Problems of the Russian Academy of Sciences, St. Petersburg, Russia http://orcid.org/0000-0002-8873-4409

Keywords: evidence-based medicine, randomized double-blind placebo-controlled trials, meta-analysis, peptide drugs

Abstract

The article reviews the efficacy and safety of medicinal peptide drugs from the perspective of evidence-based medicine. With regard to medicinal drugs, evidence-based medicine relies on the analysis of information obtained by assessing the benefits and risks of clinical trials and, in particular, randomized double-blind placebo-controlled trials. Based on a systematic review, a metaanalysis, which is a summary and statistical analysis of the results of multiple studies, was performed. This analysis of reported statistical studies proved the unconditional clinical efficacy of medicinal peptide drugs.

Medicinal peptide drugs in evidence-based medicine

Abstract