Universal mechanisms of mercury toxicity

  • A A Tinkov Department of Biochemistry, Orenburg State Medical Academy, Orenburg, 460000, Sovetskaya St., 6
  • O P Айсувакова Department of Chemistry and Methods of Chemistry Teaching, Orenburg State Pedagogical University, Orenburg, 460014, Sovetskaya st., 19
  • М Г Skalnaya Autonomous non-commercial organization «Centre for Biotic Medicine», Moscow 105064, Zemlyanoy Val St. 46
  • E V Popova Department of Biochemistry, Orenburg State Medical Academy, Orenburg, 460000, Sovetskaya St., 6
  • A I Sinitskiy Department of chemistry of the pharmaceutical faculty, South Ural State Medical University, Chelyabinsk, 453092, Vorovskogo st., 64
  • O N Nemereshina Department of Biochemistry, Orenburg State Medical Academy, Russia, Orenburg, 460000, Sovetskaya St., 6
  • E R Gatiatulina Department of Biochemistry, Orenburg State Medical Academy, Orenburg, 460000, Sovetskaya St., 6
  • A V Skalny Laboratory of biotechnology and applied bioelementology, Yaroslavl State University, Russia, Yaroslavl, 150000, Sovetskaya st., 14
  • A A Nikonorov Department of Biochemistry, Orenburg State Medical Academy, Orenburg, 460000, Sovetskaya St., 6
Keywords: mercury, oxidative stress, inflammation, endoplasmic reticulum stress

Abstract

Mercury is the one of the most toxic inorganic pollutants. Despite the presence of multiple pathologic states associated with mercury exposure, their pathogenesis involves universal mechanisms of mercury toxicity. The existing scholarly data indicate a significant role of oxidative and endoplasmic reticulum stress and inflammation in mercury toxicity. The present review summarizes current data on prooxindant effect of mercury, its influence on certain enzymatic and non-enzymatic antioxidants. The development of endoplasmic reticulum stress and inflammation in response to mercury exposure is also reviewed. The existing data indicate a significant therapeutic potential of modulation of these processes in treatment of mercury intoxication.

Published
2017-12-29
How to Cite
Tinkov, A. A., АйсуваковаO. P., SkalnayaМ. Г., Popova, E. V., Sinitskiy, A. I., Nemereshina, O. N., Gatiatulina, E. R., Skalny, A. V., & Nikonorov, A. A. (2017). Universal mechanisms of mercury toxicity. Patogenez (Pathogenesis), 13(4), 18-27. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/40
Issue
Vol. 13 No. 4 (2015): Pathogenesis
Section
Reviews