Экспериментальная оценка производных пиримидина на моделях токсического поражения печени: обзор

V. A. Myshkin; D. A. Enikeev; D. V. Srubilin; A. R. Gimadieva

V. A. Myshkin Ufa Institute of Occupational Health and Human Ecology, Ufa, Russia
D. A. Enikeev Bashkirian State Medical University, Ufa, Russia
D. V. Srubilin Bashkirian State Medical University, Ufa, Russia
A. R. Gimadieva Institute of Organic Chemistry of Ufa RAS Scientific Centre, Ufa, Russia https://orcid.org/0000-0002-2995-310X

Keywords: hepatotoxicity, oxidative stress, pyrimidine derivatives, hepatotoxins, oxymethyluracil, antioxidants, lipid peroxidation

Abstract

The review focuses on the role of antioxidants of pyrimidine patterns in overcoming hepatotoxicity of persistent organic pollutants. Special attention is paid to oxymethyluracil (5-hydroxy-6-methyluracil). The experimental results of studies on antioxidant properties and hepatoprotective effects of 6-methyluracil derivatives and their complex compounds with succinate, ascorbate, fumarate, glutathione and acetylcysteine using the liver damage models induced by chlorinated hydrocarbons and PCB-containing agents "sovtol-1" and "sovol" have been summarized. According to the intensity of hepatoprotective effects oxymethyluracil does not yield to the hepatoprotector "silimarine" using the models of liver damage caused by tetrachlormethane, PCB-containing agent "sovtol-1" and surpasses it in liver damage models induced by dichloromethane and the combination of "sovtol-1" + ethanol.

Experimental evaluation of pyrimidine derivatives using models of the toxically damaged liver: a review

Abstract