Антитела к нейромедиаторам – возможные биомаркеры предрасположенности к аддиктивному поведению

T. V. Davydova; L. A. Vetrile; T. I. Nevidimova; T. P. Vetlugina; V. G. Fomina; E. I. Batukhtina; N. A. Bohan; I. A. Zakharova; D. N. Savochkina

T. V. Davydova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
L. A. Vetrile Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
T. I. Nevidimova Mental health Research Institute of the Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation
T. P. Vetlugina Mental health Research Institute of the Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation
V. G. Fomina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
E. I. Batukhtina Mental health Research Institute of the Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation
N. A. Bohan Mental health Research Institute of the Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation
I. A. Zakharova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
D. N. Savochkina Mental health Research Institute of the Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russian Federation

Keywords: antibodies, neurotransmitters, dopamine, noradrenapine, serotonin, glutamate, GABA, addictive behavior, psychoactive substances

Abstract

Observations on 80 student volunteers of secondary specialized and higher educational institutions in Tomsk showed a decrease in the level of autoantibodies to norepinephrine, dopamine and serotonin in the blood serum of persons at risk for developing dependence on psychoactive substances. The level of antibodies to glutamate and GAM K in the blood sera of students at risk for developing dependence on psychoactive substances did not differ from the control group of students who did not use psychoactive substances. The results obtained indicate the involvement of autoantibodies to norepinephrine, dopamine and serotonin in the mechanisms of development of predisposition to addiction diseases and indicate the possibility of their use as biomarkers of predisposition to addictive behavior.

Antidodies to neuromediators – possible biomarkers of predisposion to addictive behavior

Abstract