Insulin-like growth factors and their transporting proteins in malignant bone tumors prognosis

  • N. E. Kushlinskiy N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • Yu. S. Timofeev N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • I. V. Babkina N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • D. V. Rogozin N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • V. Yu. Roshchin N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • I. V. Bulytcheva N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
  • Yu. N. Soloviev N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
Keywords: IGF-1, IGF-2, IGFBP-1, IGFBP-3, bone tumors, relapse-free survival, overall survival

Abstract

We show the study data of insulin-like growth factor system components — IGF-I, IGF-II. IGFBP-1, IGFBP-3 in 74 patients with malignant bone tumors, 14 borderline and 25 benign tumors before specific treatment. The association of elevated IGF-I basic levels with relapse-free and overall survival was detected. The connection between high IGF-II levels and unfavorable prognosis of relapse-free survival was shown in our study. High serum concentrations of IGFBP-1 and IGFBP-3 was associated with low overall survival in sarcoma patients.

Published
2023-05-26
How to Cite
Kushlinskiy, N. E., Timofeev, Y. S., Babkina, I. V., Rogozin, D. V., Roshchin, V. Y., Bulytcheva, I. V., & Soloviev, Y. N. (2023). Insulin-like growth factors and their transporting proteins in malignant bone tumors prognosis. Patogenez (Pathogenesis), 12(2), 32-36. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/624
Issue
Vol. 12 No. 2 (2014): Патогенез
Section
Original investigations