Influence of experimental gestational diabetes mellitus on the expression of immune subunits of the proteasome LMP-2 and autoimmune regulator AIRE in the thymus

Abstract

In experlment expression peculiarllies of AIRE-protein and immune proteasomes subunit LMP-2 in EGD rat thymus were researched and discussed. Immunohistochemistry and double immunofluorescence with using monoclonal antibodies to AIRE, LMP-2, CD4-antigen and rat cytokeratins were applied for AIRE and LMP-2 determination. We have establish that rats offsprings with EGD had changes with thymus expression level LMP-2 and AIRE, that can influence on pancreatic antigen representation and its processing, being offsprings risk autoimmune pathology development factor.