Peculiarities of vegetative dysfunction, system activity of proinflammatory cytokines and oxidative stress status in patients with chronic heart failure and depressive disorders

  • A. P. Baranov Russian national scientific medical University n. a. N.I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russia
  • A. V. Strutinskiy Russian national scientific medical University n. a. N.I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russia
  • L. F. Panchenko FSBSI "Research Institute of General Patology and Pathophysiology", Moscow, Russia
  • B. V. Davidov FSBSI "Institute of general pathology and pathophysiology", Moscow, Russia
  • G. P. Stepanova FSBSI "Research Institute of Medico-biological problems", Moscow, Russia
  • E. V. Gorbacheva Russian national scientific medical University n. a. N.I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russia
  • Yu. Yu. Golubev Russian national scientific medical University n. a. N.I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russia
Keywords: chronic heart failure, depressive disorders, proinflammatory cytokines, oxidative stress

Abstract

We studied the peculiarities of vegetative regulation violations heart functions, system activity of proinflammatory cytokines and oxidative stress status in 82 patients with chronic heart failure (CHF) II—III NYHA FC with anxiety-depressive disorders compared with 56 patients with CHF which have no signs of depression. It is shown that the presence of heart failure patients for signs of anxiety-depressive disorders leads to more pronounced violations of autonomic regulation of the heart, unbalanced hypersympathicotonia which contributes significant activation of proinflammatory cytokines and further oxidative stress, which are important pathogeneses mechanisms of formation and progression of heart failure.

Published
2017-12-26
How to Cite
Baranov, A. P., Strutinskiy, A. V., Panchenko, L. F., Davidov, B. V., Stepanova, G. P., Gorbacheva, E. V., & Golubev, Y. Y. (2017). Peculiarities of vegetative dysfunction, system activity of proinflammatory cytokines and oxidative stress status in patients with chronic heart failure and depressive disorders. Patogenez (Pathogenesis), 14(2), 66-70. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/65
Issue
Vol. 14 No. 2 (2016): Pathogenesis
Section
Original investigations