Achievements in therapy of atherosclerosis

  • A. V. Temchenko Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow Region, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russian Federation
  • N. G. Nikiphorov Russian Cardiology Research and Production Complex, Moscow, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative CenterMoscow, Russian Federation
  • V. A. Orekhova Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russian Federation
  • A. A. Melnichenko Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russian Federation
  • V. P. Karagodin Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russian Federation
  • I. A. Sobenin Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • A. N. Orekhov Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russian Federation; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russian Federation
Keywords: atherosclerosis, coronary artery disease, intravascular ultrasound, magnetic resonance imaging, computed tomography

Abstract

Atherosclerosis is the main reason of high morbidity and mortality in the world. To date, numerous studies of medicines which decrease mortality due to cardiovascular diseases (CVD) and/or facilitate regression of atherosclerotic lesions have been conducted. Parameters assessed in the clinical studies are total mortality, mortality due to CVD and myocardial infarction risk. Using a few biomarkers, new drugs efficiency can be tested quickly and comprehensively. Therapy with statins targeted to low density lipoprotein metaboiism was shown to promote atherosclerosis regression. A group of new drugs affecting high density lipoprotein metabolism or inflammatory and oxidative processes are currently under investigation and believed to be effective in atherosclerosis regression. This paper reviews studies on the newest anti-atherosclerotic drugs with cutting-edge imaging methods used to estimate atherosclerosis severity.

Published
2023-05-23
How to Cite
Temchenko, A. V., Nikiphorov, N. G., Orekhova, V. A., Melnichenko, A. A., Karagodin, V. P., Sobenin, I. A., & Orekhov, A. N. (2023). Achievements in therapy of atherosclerosis. Patogenez (Pathogenesis), 11(3), 13-21. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/658
Issue
Vol. 11 No. 3 (2013): Патогенез
Section
Reviews